The Blues made it back-to-back away wins when coming from behind to beat Arsenal 2-1 at the weekend while the Seagulls were in good form when comfortably dispatching of Bournemouth 2-0 in their previous fixture.
Willian has 5 goals in all competitions this scoring and the Brazilian winger is 15/2 to open the scoring against Brighton.
Nigel Pearson’s Hornets lifted themselves off the foot of the Premier League table with a 3-0 win against Aston Villa at the weekend. Nonetheless, Bet365 make Nuno Espirito Santo’s side firm favourites to put their Anfield disappointment behind them at 6/5 while a home win is priced up at a rather appealing 9/4.
There is a trio of games at 5:30pm with the pick of the bunch coming from the Etihad as Manchester City host Carlo Ancelotti’s Everton.
The Citizens can reduce Liverpool’s lead at the summit to 11-points and they are just 2/7 to win with Bet365.
The Red Devils, meanwhile, enjoyed a much more productive Festive period with wins over Newcastle and Burnley with Ole Gunnar Solskjaer likely to be particularly buoyed by the improved form of his strikers Anthony Martial & Marcus Rashford.